一、时 间： 2012年12月3日（星期一）下午2:30
二、地 点： 国家重点学科实验室大楼8楼学术活动室
三、报告题目与主持人
（一）Platelet activation and Thrombolytic therapy: Pathogenesis and treatment of heart attack and stroke
Frederick A. Ofosu MD, PhD
Professor，McMaster University, Canada
主持人：胡质毅博士、教授
（二）How I treat cardiovascular diseases (or TBA)
Dr. George S. Lavenson MD, PhD
Diplomate American Board of Surgery, University of Hawaii, USA
主持人：胡质毅博士、教授
（三）Platelets are vesitile cells: Roles of platelets in hemostasis, inflammation, and cardiovascular diseases
Heyu Ni（倪合宇） MD, PhD
Professor，Department of Physiology at the University of Toronto, Canada.
主持人：潘华峰博士、教授
四、报告人简介：
倪博士在加拿大Manitoba大学获得免疫学博士学位，之后在美国哈佛医学院完成博士后研究。目前在加拿大Toronto大学主要从事有关粘附分子在止血和血栓方面的科研工作，同时，他的实验室也在异常和自身免疫疾病涉及到的出血紊乱的研究中也有较好成果。主持由Canadian Institutes of Health Research (CIHR), Heart，Stroke Foundation of Canada (HSFC)，Canadian Blood Services (CBS)和Canadian Foundation for Innovation (CFI)资助的多项科研项目。近年来在PNAS, Blood， Journal of Thrombosis 和 Journal of Experimental Medicine等主流杂志上，以通讯作者等身份发表40余篇文章。 现为 Blood，Journal of Clinical Investigation，Journal of Biological Chemistry，Arteriosclerosis，Thrombosis和 Vascular Biology等12个国际期刊的独立审稿人。
五、报告摘要：
Platelets play key roles in hemostasis and thrombosis. Recent studies found that platelets contain significant amounts of P-selectin, TLRs, CD40/CD40L, TGF-b and other inflammatory factors. They also contain both pro- and anti-angiogenic factors. Thus, platelets are versatile cells and significantly contribute to inflammation, immune responses, and angiogenesis. We further demonstrated that Fg/VWF-independent platelet aggregation can be induced in vitro under more physiological conditions (i.e. non-anticoagulated blood) and that b3 integrin (GPIIbIIIa) is the platelet receptor required for this non-classical mechanism of platelet aggregation. Interestingly, although no alterations has been observed in levels of plasma fibronectin (pFn), thrombospondin-1, and vitronectin in Fg/VWF-/- mice, platelet fibronectin contents are markedly increased in fibrinogen deficient mice and human patients. To examine whether plasma fibronectin (pFn) is the alternative b3 integrin ligand mediating this novel platelet aggregation pathway, we generated Fg/VWF/pFn-/- triple knockout mice. Surprisingly, platelet aggregation and thrombus formation in Fg/VWF/pFn-/- mice were not abolished but were enhanced, as compared with Fg/VWF-/- mice. Our data demonstrate that pFn is a supportive factor in hemostasis but a regulatory factor in thrombosis. Several novel ligands of b3 integrin have been identified and their roles in thrombosis and hemostasis are studied.
热烈欢迎广大师生参加！
研究生院、211办
2012.12.01
